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Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B
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Citations
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References
2015
Year
Combinatorial ChemistryMolecular BiologyChemical BiologyChemical DerivativePharmaceutical ChemistryMedicinal ChemistryMonoester DerivativesBiochemistryOligonucleotideNatural Product SynthesisPharmacologyProtein PhosphorylationNatural SciencesPhosphonate MonoestersPotential InhibitorsHuman Serum AlbuminMedicineDerivative (Chemistry)Synthetic ChemistryDrug Discovery
Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.
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