Effects of <i>Schisandra chinensis</i> extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca ²⁺ homeostasis in CSM cells

Abstract

• SCE induced relaxation of CSM that occurred primarily via an endothelium-independent pathway. • The relaxation effects of SCE on CSM were, in part, due to the activation of K(+) channels and inhibition of TRPC6 channels, resulting in decreased [Ca(2+)](i).