Seizure Suppression by Adenosine A₁ Receptor Activation in a Mouse Model of Pharmacoresistant Epilepsy

Abstract

This study demonstrates that activation of central adenosine A1 receptors leads to the suppression of seizure activity in a mouse model of drug-resistant epilepsy. We conclude that the local delivery of adenosine into the brain is likely to be effective in the control of intractable seizures.