Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-d-aspartate Receptor Blockade in the Rat

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

Clifford J. Woolf · Pain · 1991 · 2K citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

NMDA receptors - their role in long-term potentiation

Graham L. Collingridge, Tim Bliss · Trends in Neurosciences · 1987 · 1.2K citations

Medicine, Neurotransmitter, Nmda Receptors +4

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

Thomas M. Jessell, Leslie L. Iversen · Nature · 1977 · 967 citations

Health Sciences, Pain Medicine, Substance P Release +11

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

J Mao, D.J. Mayer · Journal of Neuroscience · 1994 · 453 citations · Full text

Morphine Tolerance, Thermal Hyperalgesia, Pain Medicine +17