Rh^I‐Catalyzed Site‐Selective Decarbonylative Alkenylation and Arylation of Quinolones under Chelation Assistance

Abstract

Abstract An efficient catalytic system for the C‐2 selective C–H functionalization of 4‐quinolones was developed by using a decarbonylative coupling strategy. The installation of an N ‐pyrimidyl group on the quinolone nitrogen atom redirected the coordination between the catalyst and the carbonyl group to promote direct C–H functionalization at the 2‐position of 4‐quinolones. In addition, the present protocol was successfully applied to the C‐3 selective installation of a variety of aryl and vinyl groups on an isoquinolone scaffold.