The Solubility of Amino Acids, Diglycine, and Triglycine in Aqueous Guanidine Hydrochloride Solutions

Abstract

Abstract The solubilities of amino acids, diglycine, and triglycine have been measured in water and 1 m to 6 m guanidine hydrochloride solutions. Free energies of transfer of amino acid side chains and backbone peptide units from water to guanidine hydrochloride solutions have been calculated from these data. The results show similarity between the patterns of solubilizing effects of guanidine hydrochloride and urea, although guanidine hydrochloride is 2 to 3 times more effective than urea at the same concentrations.