Infection and Immunity · 1995 · 38 citations · 21 references
Veterinary MedicineImmunologyImmunizationVaccine ImmunologyVaccinologyRecombinant Protein VaccinesRecombinant Vaccine DevelopmentToxoid VaccinesVaccinationVaccine Antigen DesignVaccine Antigen DiscoveryLight Chain StructureTetanus Toxoid VaccineToxin AntigenicityToxin VaccinesToxoid Vaccine Formulation
Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.
21
Mutants of Pertussis Toxin Suitable for Vaccine Development
Mariagrazia Pizza, Antonio Covacci, Antonella Bartoloni et al. · Science · 1989 · 317 citations
Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.
Ulrich Eisel, W. Jarausch, K. Goretzki et al. · The EMBO Journal · 1986 · 308 citations · Full text