Proinflammatory cytokines in the saliva of patients with active and non-active Crohn's disease

Abstract

In patients with active CD, salivary IL-1β, IL-6, and TNF-α levels are higher than in patients with inactive disease and controls. Elevated salivary IL-6 and TNF-α levels correlate with specific oral lesions. These cytokines may be used as markers of active CD, but the finding should be confirmed in a larger group of patients.