The Discoidin Domain Receptor 2/Annexin A2/Matrix Metalloproteinase 13 Loop Promotes Joint Destruction in Arthritis Through Promoting Migration and Invasion of Fibroblast‐like Synoviocytes

Abstract

Annexin A2 is a key molecule in the DDR-2/annexin A2/MMP-13 loop, the activation of which contributes to joint destruction in RA, mainly through promoting invasion of FLS. Annexin A2 might therefore become a novel clinical target for RA treatment.