Murine genetic deficiency of neuronal nitric oxide synthase (<scp>nNOS</scp>^‐/‐) and interstitial cells of <scp>C</scp>ajal (<scp>W</scp>/<scp>W^v</scp>): Implications for achalasia?

Abstract

The reduction of ICC-IM and nNOS can cause dysfunction of the LES and esophageal peristalsis, whereas VIP reduction seems to have no effect. ICC-IM and nNOS deficiency might be independent relevant causes of esophageal dysfunction similar to that seen in human achalasia.