Publication | Closed Access
Pectenotoxin's ABCDE Ring System: A Complex Target to Test the Potential of Singlet Oxygen Super Cascades as Tools for Synthesis
12
Citations
38
References
2015
Year
Super CascadeEngineeringMolecular BiologyOrganic ChemistryChemical BiologyRedox BiologyBiosynthesisSinglet OxygenNatural Product BiosynthesisAbcde Ring SystemBiochemistryBiocatalysisDiversity-oriented SynthesisComplex TargetA Difuran SubstrateNatural Product SynthesisBiomolecular EngineeringNatural SciencesSynthetic Biology
Abstract A difuran substrate was synthesized that then participated in a singlet oxygen mediated super cascade reaction sequence to give the ABCDE ring skeleton of certain pectenotoxins. During this super cascade, two separate reaction sequences occurred in parallel to create both the [6,6]‐spiroketal and the 2,8‐dioxabicyclo[3.2.1]octane motifs in one synthetic operation.
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