Chromosomal stability during ex vivo expansion of UCB CD34+ cells

Abstract

Ex vivo expansion could lead to occurrence of chromosomal abnormality, although here it did not produce excessive proliferative advantage of the expended cells. Importantly, chromosomal alteration seemed not to be inheritable and unlikely to result in malignant transformation. However, further in-depth evaluation of potential clinical risks of chromosomal abnormality is warranted.