Antibody levels correlate with detection of <i>Trypanosoma cruzi</i> DNA by sensitive polymerase chain reaction assays in seropositive blood donors and possible resolution of infection over time

Abstract

For all three countries, persistent DNA positivity correlated with higher ELISA S/CO values, suggesting that high-level seroreactivity reflects chronic parasitemia. Significant S/CO declines in 10% of the PCR-negative Brazilian donors may indicate seroreversion after parasite clearance in the absence of treatment.