Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from <i>Ganoderma microsporum</i>

Abstract

We demonstrated that autophagosome accumulation induces autophagic cell death in a GMI treatment model, and ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion. Our findings provide new insights into the mechanisms involved in the induction of autophagic cell death.