Hyperactive BMP signaling induced by ALK2^R206H requires type II receptor function in a <i>Drosophila</i> model for classic fibrodysplasia ossificans progressiva

Abstract

The dual function of ALK2 is of particular interest given the heterozygous nature of FOP, as the normal interplay between such disparate behaviors could be shifted by the presence of ALK2(R206H) receptors. Our studies provide a compelling example for Drosophila as a model organism to study the molecular underpinnings of complex human syndromes such as FOP.