Spinal and peripheral analgesic effects of the CB₂ cannabinoid receptor agonist AM1241 in two models of bone cancer‐induced pain

Abstract

Spinal CB(2) receptors are involved in the antiallodynic effect induced by AM1241 in two neoplastic models while peripheral and spinal receptors participate in the antihyperalgesic effects. Both effects were mediated by endogenous opiates. The use of drugs that activate CB(2) receptors could be a useful strategy to counteract bone cancer-induced pain symptoms.