Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core–shell mesoporous silica nanoparticles

Abstract

Core-shell Fe3O4@SiO2 mesoporous silica nanoparticles coated with a new thermodegradable polymer allowed the release of a model drug through heating caused by a high frequency oscillating magnetic field. The thermodegradable polymer was made of poly(ethylene glycol) (PEG) functionalised with azo bonds that break with an elevation of temperature.