Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases.

Abstract

Exclusive brachyury expression in more than 90% of chordomas indicates its value as a unique, specific marker with other sensitive markers like cytokeratin, epithelial membrane antigen, and/or S100 protein in substantiating a diagnosis of chordoma, including on small biopsies.