Journal of Neuropsychiatry · 1995 · 55 citations · 0 references
MedicineNeurologyNeuroscienceNeuropharmacologyNeuropsychiatryPsychopharmacologyCognitive ImpairmentNeurological AssessmentNeuropsychiatric AssessmentNeuropsychiatric PharmacotherapyPsychosomatic MedicineStrokeApathy TreatmentFrontal-subcortical CircuitsMethylphenidate PharmacologyMethylphenidate TherapyMonoamine PharmacologyNeuropsychiatric EffectsSubcortical StructuresVisual Reaction Time
A patient with prominent apathy secondary to multiple subcortical infarcts was treated successfully with methylphenidate. SPECT and reaction time testing showed selective improvement of frontal system function, consistent with a recent model of frontal-subcortical circuits and behavior.