Prognostic implications of mutations in <i>NOTCH1</i> and <i>FBXW7</i> in childhood T-all treated according to the NOPHO ALL-1992 and ALL-2000 protocols

Abstract

Increased NOTCH activity, reflected by increased HES1 expression, is associated with improved outcome in pediatric T-ALL, but its role as a diagnostic tool or a therapeutic target in future clinical treatment protocols remains to be elucidated.