Concepedia

The <scp>NADPH</scp> Oxidase Nox4 mediates tumour angiogenesis

Valeska Helfinger, Nina Henke, Sabine Harenkamp, Matthew J. Walter, Jeremy Epah, Cornelia Penski, Michel Mittelbronn, Katrin Schröder

Acta Physiologica · 2015 · 53 citations · 32 references

DOI

Abstract

By regulating the tumour-vessel density through stabilization of Hif-1α and induction of VEGF expression, Nox4 promotes tumour angiogenesis and may represent a novel target for anti-angiogenic tumour therapy.

References

32

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

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Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations

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