Gene expression of TWEAK/Fn14 and IP‐10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis

Abstract

In patients with lupus nephritis, there is an increase in intra-renal expression of TWEAK and Fn14, and a decrease in CXCR3 expression. Intra-renal expression of CXCR3 correlates with proteinuria and renal function. Our findings suggest that the TWEAK/Fn14 and IP-10/CXCR3 axis may contribute to the pathogenesis of lupus nephritis.