Concepedia

The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells

Vida Foubister, Ilan Rosenshine, Michael S. Donnenberg, B. Brett Finlay

Infection and Immunity · 1994 · 138 citations · 13 references

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Abstract

An enteropathogenic Escherichia coli mutant carrying an internal deletion in the eaeB gene (UMD864) was unable to activate epithelial cell signals, including tyrosine phosphorylation, cytoskeletal rearrangements, and the release of inositol phosphates, indicating that the eaeB locus encodes a product that is involved in stimulating signals in epithelial cells.

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