Blood · 1998 · 302 citations · 239 references
Life SciencesHematologyOncologyCancer GeneticsCytogeneticsHematologic OncologyCancer CytogeneticsClinical CytogeneticsHematologic MalignanciesHematopoietic NeoplasmsLymphoid NeoplasmsMolecular CytogeneticsAcute Lymphoblastic Leukemia BiologyAcute Lymphoblastic Leukemia TherapyCytogenetic AbnormalitiesCytogenetic KaryotypingCytogenetic StabilityLeukemia ClassificationLeukemia Cytogenetics
ACUTE LYMPHOBLASTIC leukemias (ALL) are characterized by clonal proliferation, accumulation, and tissue infiltration of neoplastic cells. They are mainly regarded as childhood diseases, with an early incidence peak at 2 to 5 years of age, where they represent about 80% of the childhood leukemias in
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