Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology

Abstract

RAMP-dependent effects of CLR mutations suggest that the different RAMPs control accessibility of peptides to binding residues situated on the CLR N-terminus. RAMP3 appears to alter the role of specific residues at the CLR-RAMP interface compared with RAMP1 and RAMP2.