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Beta dose point kernels for radionuclides of potential use in radioimmunotherapy.
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1989
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Potential UseRadiation ExposureBeta Dose DistributionsImmunotherapyDose Point KernelsOncologyRadiopharmaceutical TherapyRadiation Therapy PlanningRadiation OncologyNuclear MedicineRadiologyHealth SciencesRadiation TherapyRadionuclide TherapyAlpha Particle TherapyDosimetryRadiation DoseRadiopharmaceuticalsSpatial Dose DistributionMedicine
The data enable calculation of spatial dose distributions from radiolabeled antibodies, facilitating optimal radionuclide selection. Beta dose point kernels for six radionuclides were computed via Monte Carlo, tabulated at 4 % CSDA‑range intervals, and analytic parameters for their scaled kernels were provided. The Monte Carlo kernels differ markedly from electron‑transport solutions, and for 32P they show better agreement with experimental data.
Beta dose point kernels for 32P, 67Cu, 90Y, 131I, 186Re, and 188Re nuclides appropriate for radioimmunotherapy are calculated based upon Monte Carlo results. The calculations are shown to differ significantly from values based upon solutions to the electron transport equation. Agreement with experiment for 32P is found to be improved for the former as compared with the latter. Values of the scaled dose point kernels are tabulated at 4% intervals of the continuous slowing down approximation range for each of the six radionuclides. Beta dose distributions are also tabulated at corresponding distances from the source. This data may be used to calculate the spatial dose distribution expected following administration of radiolabeled monoclonal antibodies, aiding in optimum selection of the appropriate radionuclide. Parameters for functions providing analytic representation of the calculated scaled dose point kernels of individual beta groups are presented.