Immobilization of bioactive substances on poly(alkylene phosphate)s, 1. Immobilization of 2‐phenylethylamine

Abstract

Abstract Poly(alkylene phosphate)s of low molecular weight were synthesized by polytransesterification of dialkyl phosphonates with poly(ethylene glycol)s (PEG). These poly(alkylene phosphonate)s were then converted into poly(alkylene phosphate)s by using the Atherton‐Todd reaction in methanol as a solvent. The compound 2‐phenylethylamine was immobilized on these polymers via ionic bonds. These immobilizations were achieved by both alkylation and dealkylation reactions. The final products from these reactions are the polyanions. The structures of these products were determined by a combination of 1 H, 31 P and 31 C NMR spectroscopy.