Influence of glucagon on pancreatic exocrine secretion.

Abstract

Effects of small amounts of glucagon on. pancreatic exocrine function were studied in 7 pancreatic fistula dogs in (a) the resting state, (b) during continuous intravenous infusion of secretin, and (c) during infusion of secretin with pancreozymin. Glucagon produced no significant stimulation of secretion in the resting gland but markedly depressed volume flow and enzyme concentrations in the stimulated gland. Inhibition of enzyme output was greater than was inhibition of volume and bicarbonate output.