Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. - Concepedia

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Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study.

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References

2003

Year

Norihiro Nishimoto, Kazuyuki Yoshizaki, Keiji Maeda, Taro Kuritani, Hitoshi Deguchi, Bunzo Sato, Nobuyuki Imai, Masaki Suemura, Takahiro Kakehi, Nobuhiro Takagi,

Abstract

Repetitive treatment with MRA was safe and normalized acute phase response in patients with RA. Optimal dosing schedule was not defined in this small study, but maintenance of serum MRA concentration seemed important to achieve efficacy.