Human whole‐blood ¹H₂O longitudinal relaxation with normal and high‐relaxivity contrast reagents: Influence of trans‐cell‐membrane water exchange

Abstract

In whole blood, (1) H2 O R1 exhibits a nonlinear relationship with [CR] over 0 to 18 mM CR. The nonlinearity is well described by exchange of water between erythrocyte and plasma compartments, and is particularly evident for high relaxivity CRs.