The acute toxic action of dimethylnitrosamine on liver cells

Abstract

Dimethylnitrosamine has been shown to be selectively hepatotoxic for several species of mammals, producing demonstrable necrosis within 24 hr. It is rapidly metabolized (Dutton & Heath, 1956) and Magee ( Magee (1957) also found that the incorporation of labelled amino acids into liver protein is impaired as early as 6 hr. after treatment.