Identification of Interleukin‐1β–Producing Monocytes That Are Susceptible to Pyronecrotic Cell Death in Patients With Neonatal‐Onset Multisystem Inflammatory Disease

Abstract

Our findings indicate that monocytes are the predominant IL-1β-producing cell population in the peripheral blood of NOMID patients. Furthermore, they suggest that IL-1 receptor blockade may work in part by preventing pyronecrotic cell death, which may be an important target in NOMID and other forms of cryopyrin-associated periodic syndromes.