Plasma fibrinogen: determination, normal values, physiopathologic shifts, and fluctuations.

Abstract

The determination of plasma fibrinogen, either as clottable protein or protein precipitable with glycine or ammonium sulfate, is evaluated in terms of principles of analysis, analytic error, normal and abnormal ranges, physiologic stability, and pathologic variability of fibrinogen concentration. The quantitative comparison of analytic error, population ranges, and individual variability should permit more precise interpretation of clinical data than previously has been possible.