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The Effect of Antilymphocytic Serum (ALS) on the Reticuloendothelial System (RES) of Mice
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1969
Year
Vascular DiseaseImmunologyPathologyImmunotherapyInflammationHematologyImmunopathologyMicrovascular DysfunctionCell TransplantationAtherosclerosisHealth SciencesTransplantationAutoimmune DiseaseGranulocyteAls TreatmentAutoimmunityVascular BiologySkin AllograftsPharmacologyAntilymphocytic SerumPhysiologyPathogenesisEndothelial DysfunctionReticuloendothelial SystemSummary MiceGeneral PathologyMedicine
Summary Mice treated with heterologous ALS were found to have a significantly increased clearance of 32P-labeled Salmonella typhimurium C5 particles. This enhanced activity first appeared 24 to 48 hr after injection of the antiserum and persisted in spite of the cessation of ALS treatment. The ALS used was found to produce hypertrophy of the liver, spleen and lymph nodes. Histologic studies revealed hyperplastic changes in these lymph nodes and spleens with the appearance of large numbers of cells resembling primitive plasma cells, many of which were pyroninophilic. A correlation between these changes and the time of survival of skin allografts was shown. Allografts were rejected at the time when the phagocytic activity and the histologic changes in lymph nodes and spleen returned to normal.