Long‐Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin‐1β During Antigen‐Induced Arthritis in Rats: A Mechanism of Persistent Arthritis Pain?

Abstract

Immune-mediated arthritis causes neuroplastic changes in sensory neurons that outlast the inflammatory phase. Such changes may facilitate the persistence or recurrence of pain after remission of arthritis. IL-1β is an important trigger in this process, although its neutralization barely reduced mechanical hyperalgesia during inflammation.