ORIGINAL ARTICLE: Supporting the Hypothesis of Pregnancy As a Tumor: Survivin Is Upregulated in Normal Pregnant Mice and Participates in Human Trophoblast Proliferation

Abstract

Our findings suggest an important role of survivin to promote trophoblast cell survival and proliferation during placentation, thus maintaining pregnancy. The pregnancy-associated expression of a cancer molecule such as survivin supports the 'pseudo-malignancy' hypothesis of pregnancy. Our data may contribute to the better understanding of trophoblast cell development during implantation and placentation.