Synthèse et propriétés amœbicides d'analogues de l'émétine. Analyse des composés nouveaux en ¹³C‐RMN. I. (±) Alkyl‐1‐déséthyl‐3‐émétine à jonction B/C <i>cis</i> ou <i>trans</i>

Abstract

Synthesis and amoebicid properties of emetin analogs. Analysis of the new compounds by 13 C‐NMR. B/C‐ cis or trans ‐fused (±) 1‐alkyl‐3‐desethyl‐emetin. New 1‐alkyl‐3‐desethyl‐emetines were prepared for pharmacological purposes. The usual emetine synthesis sequence applied to cis ‐1‐alkylbenzo [a]quinolizidin‐2‐ones afforded new cis ‐1‐alkyl‐3‐desethyl‐emetines. The trans ‐fused isomers were also prepared. The relative configuration are determined by 1 H‐ and 13 C‐NMR. spectra.