Non-allergic bronchial hyperreactivity in asthmatic children decreases with age and increases with mite immunotherapy.

Abstract

Bronchial reactivity to histamine increased 2-fold or greater in six of seven mite-sensitive asthmatic children after mite immunotherapy for 1 year. Bronchial reactivity decreased 2-fold or greater in seven of the eight subjects who received no injections (P = .008).