Dipeptidyl peptidase‐4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell‐derived factor‐1<i>α</i>

Abstract

Saxagliptin-mediated DPP-4 inhibition, but not liraglutide-mediated GLP-1R agonism, improved cardiac function after MI independent of glucose lowering. These findings suggest that non-GLP-1 actions of DPP-4 inhibition, such as SDF-1α potentiation, mediate biological effects.