Selectivity profiling of the novel EP₂ receptor antagonist, PF‐04418948, in functional bioassay systems: atypical affinity at the guinea pig EP₂ receptor

Abstract

Using a wide range of bioassay systems, we have demonstrated that PF-04418948 is a selective EP(2)-receptor antagonist. Interestingly, an atypically low affinity was found on the guinea pig trachea, questioning its utility as an EP(2) receptor assay system. Nevertheless, this compound should be an invaluable tool for investigating the biological activity of PGE(2) and the role of EP(2) receptors in health and disease.