Evaluation of peripheral versus central effects of <scp>GABA<sub>B</sub></scp> receptor activation using a novel, positive allosteric modulator of the <scp>GABA<sub>B</sub></scp> receptor <scp>ADX</scp>71943, a pharmacological tool compound with a fully peripheral activity profile - Concepedia

Concepedia

Publication | Open Access

Evaluation of peripheral versus central effects of <scp>GABA<sub>B</sub></scp> receptor activation using a novel, positive allosteric modulator of the <scp>GABA<sub>B</sub></scp> receptor <scp>ADX</scp>71943, a pharmacological tool compound with a fully peripheral activity profile

DOI Full Paper Access

19

Citations

37

References

2014

Year

Mikhail Kalinichev, Tansy Donovan-Rodríguez, F Girard, Eric Riguet, Mélanie Rouillier, Bruno Bournique, Hasnaà Haddouk, Vincent Mutel, Sonia Poli

British Journal of Pharmacology

Abstract

ADX71943 showed consistent and target-related efficacy in tests of disorders that have a significant peripheral component (acute and chronic pain), while having no effect in those associated with centrally-mediated anxiety-like reactivity and side effects. Thus, ADX71943 is a useful pharmacological tool for delineation of peripherally- versus centrally-mediated effects of GABA(B) receptor activation.

References

	Year	Citations

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