Mark4 promotes adipogenesis and triggers apoptosis in 3T3‐L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways

Abstract

Mark4 promotes adipogenesis in 3T3-L1 adipocytes by activating the JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway. We conclude that anti-Mark4 therapy targetted to inhibit lipid accumulation and apoptosis of adipocytes shows potential as a novel therapeutic strategy for treatment of obesity-associated metabolic complications.