Hemoglobin Petah Tikva (alpha 110 ala replaced by asp): a new unstable variant with alpha-thalassemia-like expression

Abstract

Tikva. a new unstable a-chain structural variant.was identified in two unrelated children whose families are from the Iraqi Jewish community of Baghdad.Both children have a-thalassemia.with hematologic features of mild HbH disease.The abnormal hemoglobin from the two patients did not separate from hemoglobin A by electrophoresis or chromatography.but the mutant a-chain emerged ahead of aA in carboxymethylcellulose column chromatography.allowing it to be isolated in pure form.Hemoglobin Petah Tikva was unstable in solution and could also be isolated by isopropanol precipitation.