American Journal of Epidemiology · 1977 · 126 citations · 0 references
Life SciencesGeneticsEpidemiologyGenetic EpidemiologyHuman GeneticsChronic DiseaseChronic Disease EpidemiologyChronic Obstructive Pulmonary DiseaseGenetic RiskGenetic SusceptibilityRespiratory DiseaseAbo Blood Group AntigensAbo Blood Group TypingChronic Lung Disease RiskChronic Obstructive Pulmonary Disease EpidemiologyChronic Obstructive Pulmonary Disease PathophysiologyFamily Socioeconomic StatusMendelian Risk FactorsSmoking-related Genetic Risk
In a genetic-epidemiologic study of chronic obstructive pulmonary disease (COPD) observations adjusted for age, sex, race, and smoking indicate certain factors to be associated with increased pulmonary function aberrancy, and suggest that they are risk factors for COPD. These presumptive "risk factors" include not only cigarette smoking, but also alpha1-antitrypsin (Pi system) variation, one or more other familial components, low socioeconomic status (SES), and, in whites, ABO blood type (either absence of "B" or presence of "A").