Do <scp>PT</scp> and <scp>APTT</scp> sensitivities to factors' deficiencies calculated by the H47‐A2 2008 <scp>CLSI</scp> guideline reflect the deficiencies found in plasmas from patients?

Abstract

Reagent-coagulometer combination has adequate sensitivities to factor deficiencies according to guideline recommendations (>30 IU/dL). These should not be considered as actual sensitivities because those obtained by analysing patients' plasmas with single-factor deficiencies were higher for most factors and could induce misinterpretation of the basic coagulation test results.