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Inhibition of 9,10-dimethyl-1,2-benzanthracene skin carcinogenesis in mice by polycyclic hydrocarbons.
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1951
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Chemoprevention StrategyPharmacotherapyDermatologyTumor BiologyMedicinal ChemistryCancer Cell BiologyToxicologySkin PharmacologyAnti-cancer AgentPolycyclic Aromatic HydrocarbonCancer ResearchSkin CancerMedicineCutaneous BiologyMean Latent Period9,10-Dimethyl-1,2-benzanthracene Skin CarcinogenesisPharmacologyMalignant DiseasePhotocarcinogenesisOncologySummary 1.TheMean Tumor Yield
Summary 1.The admixture of 6,8-dimethyl-1,2-benzanthracene or of 1,2,5,6-dibenzofluorene prolonged the mean latent period and reduced the mean yield of tumors induced in the skin of mice by application of 9,10-dimethyl-1,2-benzanthracene. 2.The mean latent period was prolonged, but the mean tumor yield was not reduced by admixture of 1,2-benzanthracene, or of 2-, 7-, or 8-methyl-1,2-benzanthacene. Anthracene caused slight prolongation of latent period. 3.Naphthalene and fluorene had no inhibitory effect. 4.The progression of established tumors and the mean duration of life after development of a tumor were not significantly affected by mixture of any of the compounds with 9,10-dimethyl-1,2-benzanthracene. 5.1,2-Benzanthracene, 2′-methyl-1,2-benzanthracene, 6,8-dimethyl-1,2-benzanthracene, and 1,2,5,6-dibenzofluorene were weakly carcinogenic when tested for carcinogenicity under conditions comparable to those under which they caused inhibition.