The Determination of Antibiotic Resistance of Helicobacter Pylori Isolated from Patients Living in North of Iran (Sari)

Abstract

Background: Helicobacter pylori (H. pylori), which infects about half of the world's population, is the main factor to peptic and duodenal ulcer diseases. Resistance to antibiotics is the main reason of failure of H. pylori treatment. Objective: Since the antibiotic resistance patterns of H. pylori is varied geographically; therefore, the main purpose of this study was to determine the antibacterial effects on H. pylori infection. Material and methods: The cross-sectional study was conducted on 120 patients (51 male, 69 female) with upper Gastrointestinal symptoms which they had referred to endoscopy department. Demographic characteristics of patients were recorded prior to sampling and the situations of resistance to 6 commonly used antibiotics in treating of H. pylori infection were studied. Results: In this study, 30 isolates were obtained from the culture of gastric biopsy specimens of 120 patients. The resistance rate of H. pylori to Metronidazole, Clarithromycin, Tetracycline, Amoxicillin and Levofloxacin were 63.3%, 16.6%, 6.6%, 10% and 3.3%, respectively. There was no resistance rate of H. pylori to Furazolidone during observation. Conclusion: According to antibiotic resistance level of this study, it seems that the antibiotic susceptibility tests are always necessary in order to determine the appropriate drug regimen against to H. pylori.