THE LACK OF GROWTH OF INTRAVENOUSLY INOCULATED TUMOR CELLS IN PERIPHERAL WOUNDS.

Abstract

Various doses of Walker 256 and Guerin tumor suspensions were injected intravenously into groups of rats which had been subjected to incisions of skin and muscle less than 1 hour previously. Similar experiments were conducted with Sarcoma 180 and V2 carcinoma of mice and rabbits, respectively. Following intravenous injection of cancer cells no metastases were noted in the scars of 520 incisions made in rats, in 40 incisions made in mice, and in sixteen incisions in rabbits. In no animal did the intravenous injection of tumor cells result in the growth of a metastasis in an incision. However, when one million V2 carcinoma cells were given intra-arterially , four tumors were found in 24 incisions made in nine rabbits.