Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in<i>TCF4</i>

Abstract

The Krachmer grade of disease severity was greater in FECD cases with the CTG18.1 triplet repeat expansion in TCF4 than in those without the expansion. The CTG triplet repeat allele length was positively correlated with the Krachmer grade of severity. The TCF4 triplet repeat expansion resulted in a more severe form of FECD, with clinical and surgical therapeutic implications.