Cooperative role of tumour necrosis factor‐α, interleukin‐1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice

Abstract

In conclusion, the present study describes a new model that allows for the concomitant evaluation of articular hypernociception and inflammation. Using this system, we demonstrated that a positive feedback loop involving neutrophil influx and the pro-inflammatory cytokines TNF-α and IL-1β is necessary for articular hypernociception after antigen challenge of immunized mice.